PTPN6 monoclonal antibody, clone PTY10
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Specifications
Product Description
Mouse monoclonal antibody raised against full length recombinant PTPN6.
Immunogen
Recombinant protein corresponding to full length human PTPN6.
Host
Mouse
Theoretical MW (kDa)
67
Reactivity
Human
Specificity
This antibody recognizes single 67 KDa PTPN6 in human cells that express the enzyme and the SH2(C) domain.
Form
Lyophilized
Isotype
IgG2a, kappa
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
Lyophilized from 10 mM PBS, pH 7.2
Storage Instruction
Store at -20°C.
Aliquot after reconstitution to avoid repeated freezing and thawing. -
Applications
Western Blot
Lane 1, 3, 5, 7, 9 using PTPN6 expression supernant 10 ul.
Lane 2, 4, 6, 8, 10 using Ni column purified PTPN6 expression supernant 5 ul.Western Blot
Immunocytochemistry
Enzyme-linked Immunoabsorbent Assay
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Gene Info — PTPN6
Entrez GeneID
5777Gene Name
PTPN6
Gene Alias
HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1
Gene Description
protein tyrosine phosphatase, non-receptor type 6
Omim ID
176883Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq
Other Designations
hematopoietic cell phosphatase|hematopoietic cell protein-tyrosine phosphatase|protein-tyrosine phosphatase 1C
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Interactomes
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Pathways
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Diseases
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