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Last updated: 2014/11/23
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HLA-A/HLA-B/HLA-C monoclonal antibody, clone LY5.1

  • Catalog # : MAB6383
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against HLA-A/HLA-B/HLA-C.
  • Immunogen:
  • Purified human HLA-A/HLA-B/HLA-C complex.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Isotype:
  • IgG1, kappa
  • Recommend Usage:
  • The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 10 mM PBS, pH 7.2
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Immunohistochemistry
  • Application Image
  • Immunohistochemistry
  • Gene Information
  • Entrez GeneID:
  • 3105
  • Gene Name:
  • HLA-A
  • Gene Alias:
  • HLAA
  • Gene Description:
  • major histocompatibility complex, class I, A
  • Gene Summary:
  • HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq
  • Other Designations:
  • HLA class I histocompatibility antigen, A-23 alpha chain,MHC class I antigen HLA-A heavy chain,MHC leukocyte antigen,OTTHUMP00000161059,antigen presenting molecule,leucocyte antigen class I,leukocyte antigen class I-A
  • Gene Information
  • Entrez GeneID:
  • 3106
  • Gene Name:
  • HLA-B
  • Gene Alias:
  • AS,HLA-B-7301,HLA-B73,HLAB,HLAC,SPDA1
  • Gene Description:
  • major histocompatibility complex, class I, B
  • Gene Summary:
  • HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq
  • Other Designations:
  • HLA class I histocompatibility antigen, B alpha chain,HLA class I histocompatibility antigen, B-7 alpha chain,HLA class I histocompatibility antigen, Cw-5 alpha chain,HLA-B alpha chain (HLA-B*7301),MHC Class I HLA heavy chain,MHC HLA-B cell surface glycop
  • Gene Information
  • Entrez GeneID:
  • 3107
  • Gene Name:
  • HLA-C
  • Gene Alias:
  • D6S204,FLJ27082,HLA-Cw,HLA-Cw12,HLA-JY3,HLC-C,PSORS1
  • Gene Description:
  • major histocompatibility complex, class I, C
  • Gene Summary:
  • HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq
  • Other Designations:
  • HLA class I antigen,HLA class I heavy chain,HLA class I histocompatibility antigen, C alpha chain,HLA-C (Cw*1201),HLA-Cw*050x,MHC class I HLA-C,MHC class I HLA-Cw*0803,MHC class I antigen HLA-C,MHC class I antigen heavy chain HLA-C,MHC class I protein HLA
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