ANPEP monoclonal antibody, clone 22A5 (FITC)
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Specification
Product Description
Mouse monoclonal antibody raised against ANPEP.
Immunogen
Cell suspension containing osteoclasts from human osteoclastomas.
Host
Mouse
Reactivity
Human
Specificity
Specificity human CD13
Form
Liquid
Conjugation
FITC
Isotype
IgG2a
Recommend Usage
Flow Cytometry (10 ul/106 cells)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Frozen sections)
Immunoprecipitation
Flow Cytometry
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Gene Info — ANPEP
Entrez GeneID
290Gene Name
ANPEP
Gene Alias
APN, CD13, LAP1, PEPN, gp150, p150
Gene Description
alanyl (membrane) aminopeptidase
Omim ID
151530Gene Ontology
HyperlinkGene Summary
Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq
Other Designations
OTTHUMP00000194690|aminopeptidase M|aminopeptidase N|membrane alanine aminopeptidase|microsomal aminopeptidase
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Interactome
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Pathway
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Disease
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Publication Reference
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T cell responses affected by aminopeptidase N (CD13)-mediated trimming of major histocompatibility complex class II-bound peptides.
Larsen SL, Pedersen LO, Buus S, Stryhn A.
The Journal of Experimental Medicine 1996 Jul; 184(1):183.
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1F7 (CD26): a marker of thymic maturation involved in the differential regulation of the CD3 and CD2 pathways of human thymocyte activation.
Dang NH, Torimoto Y, Shimamura K, Tanaka T, Daley JF, Schlossman SF, Morimoto C.
Journal of Immunology 1991 Nov; 147(9):2825.
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T cell responses affected by aminopeptidase N (CD13)-mediated trimming of major histocompatibility complex class II-bound peptides.
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