IL5 monoclonal antibody, clone JES1-39D10 (Biotin)
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Specification
Product Description
Rat monoclonal antibody raised against recombinant IL5.
Immunogen
Recombinant protein corresponding to human IL5.
Host
Rat
Reactivity
Human
Specificity
human Interleukin-5 (IL-5)1-4.
Form
Liquid
Conjugation
Biotin
Isotype
IgG2a, kappa
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — IL5
Entrez GeneID
3567Gene Name
IL5
Gene Alias
EDF, IL-5, TRF
Gene Description
interleukin 5 (colony-stimulating factor, eosinophil)
Omim ID
147850Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. This cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes. The receptor of this cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. This cytokine, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq
Other Designations
B cell differentiation factor I|OTTHUMP00000065830|T-cell replacing factor|eosinophil differentiation factor|interleukin 5|interleukin-5
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Interactome
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Publication Reference
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Interleukin-4 and interleukin-5 are rarely co-expressed by human T cells.
Jung T, Schauer U, Rieger C, Wagner K, Einsle K, Neumann C, Heusser C.
European Journal of Immunology 1995 Aug; 25(8):2413.
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Flow cytometric analysis for cytokine production identifies T helper 1, T helper 2, and T helper 0 cells within the human CD4+CD27- lymphocyte subpopulation.
Elson LH, Nutman TB, Metcalfe DD, Prussin C.
The Journal of Immunology 1995 May; 54(9):4294.
Application:Flow Cyt, Human, CD4+ lymphocytes.
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Interleukin-5 and the posttreatment eosinophilia in patients with onchocerciasis.
Limaye AP, Abrams JS, Silver JE, Awadzi K, Francis HF, Ottesen EA, Nutman TB.
The Journal of Clinical Investigation 1991 Oct; 88(4):1418.
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Interleukin-4 and interleukin-5 are rarely co-expressed by human T cells.
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