LBP monoclonal antibody, clone biG 42
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Mouse monoclonal antibody raised against recombinant LBP.
Immunogen
Recombinant protein corresponding to human LBP.
Host
Mouse
Reactivity
Human
Specificity
LPS binding protein (LBP) is an approximately 60 KDa acute phase protein that is produced by hepatocytes. This protein strongly binds to LPS and has been shown to play an important role in the handling of LPS by the host. A number of functions of LBP have been reported. First, LBP transfers LPS to the LPS receptor CD14 on mononuclear phagocytes, leading to a 100-1,000-fold increased sensitivity of the cells to LPS. Furthermore, LBP can enhance the response of CD14 negative cells by acceleration of LPS binding to soluble CD14, a complex that stimulates these cells. LBP was demonstrated to protect mice from septic shock caused by LPS or gram negative bacteria.
Form
Lyophilized
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from PBS
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with deionized water, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Enzyme-linked Immunoabsorbent Assay
-
Gene Info — LBP
Entrez GeneID
3929Gene Name
LBP
Gene Alias
MGC22233
Gene Description
lipopolysaccharide binding protein
Omim ID
151990Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). Finally, this gene is found on chromosome 20, immediately downstream of the BPI gene. [provided by RefSeq
Other Designations
LPS-binding protein|OTTHUMP00000030965|lipopolysaccharide-binding protein
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
Local expression of lipopolysaccharide-binding protein in human gingival tissues.
Ren L, Jin L, Leung WK.
Journal of Periodontal Research 2004 Aug; 39(4):242.
Application：IHC, Human, Human healthy gingival biopsy.
-
Local expression of lipopolysaccharide-binding protein in human gingival tissues.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com