KRT18 monoclonal antibody, clone SB38b
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More Files
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Immunofluorescence
Cell cytospin of the HCC38 breast carcinoma cell line was incubated with KRT18 monoclonal antibody, clone SB38b (Cat # MAB5630). Positive cells were viewed by fluorescence microscopy.
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant KRT18.
Immunogen
Recombinant protein corresponding to N-terminus of human KRT18.
Host
Mouse
Reactivity
Human
Specificity
Cytokeratin 18.
Form
Liquid
Isotype
IgG2b
Recommend Usage
ELISA (1:5000-1:20000)
Immunohistochemistry (10 ug/mL)
Western Blot (1:2000-1:4000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 100 mM BBS, pH 8.2
Storage Instruction
Store at 4°C.
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Applications
Western Blot
Immunohistochemistry (Frozen sections)
Immunofluorescence
Cell cytospin of the HCC38 breast carcinoma cell line was incubated with KRT18 monoclonal antibody, clone SB38b (Cat # MAB5630). Positive cells were viewed by fluorescence microscopy.Enzyme-linked Immunoabsorbent Assay
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Gene Info — KRT18
Entrez GeneID
3875Gene Name
KRT18
Gene Alias
CYK18, K18
Gene Description
keratin 18
Gene Ontology
HyperlinkGene Summary
KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
Other Designations
cell proliferation-inducing protein 46|cytokeratin 18
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Interactome
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Pathway
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Disease
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Publication Reference
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Keratin 8 and 18 mutations are risk factors for developing liver disease of multiple etiologies.
Ku NO, Darling JM, Krams SM, Esquivel CO, Keeffe EB, Sibley RK, Lee YM, Wright TL, Omary MB.
PNAS 2003 May; 100(10):6063.
Application：IF, IP-WB, Human, Liver.
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Complete structure of the gene for human keratin 18.
Kulesh DA, Oshima RG.
Genomics 1989 Apr; 4(3):339.
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Molecular and cellular biology of intermediate filaments.
Steinert PM, Roop DR.
Annual Review of Biochemistry 1988 Jan; 57:593.
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Keratin 8 and 18 mutations are risk factors for developing liver disease of multiple etiologies.
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