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EGFR monoclonal antibody, clone F4 (Biotin)

  • Catalog # : MAB5447
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against synthetic peptide of EGFR.
  • Immunogen:
  • A synthetic peptide (conjugated with KLH) corresponding to amino acids 985-996 of human EGFR.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • Recognizes the internal domain with an epitope between amino acids 985-996 from the complete EGF receptor sequence of 1206 amino acids. It is thus about 200 residues from the C-terminus but just outside the region of sequence homology shared by the src oncogene family.
  • Form:
  • Liquid
  • Conjugation:
  • Biotin
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Immunohistochemistry (1:50)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 10 mM potassium phosphate buffer, 150 mM NaCl, 2 mM EDTA, pH 7.25 (1% BSA, 0.1% sodium azide)
  • Storage Instruction:
  • Store at 4°C. Do not freeze.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Application Image
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Gene Information
  • Entrez GeneID:
  • 1956
  • Gene Name:
  • EGFR
  • Gene Alias:
  • ERBB,ERBB1,HER1,PIG61,mENA
  • Gene Description:
  • epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
  • Gene Summary:
  • The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq
  • Other Designations:
  • avian erythroblastic leukemia viral (v-erb-b) oncogene homolog,cell growth inhibiting protein 40,cell proliferation-inducing protein 61,epidermal growth factor receptor
  • Interactome
  • Related Disease
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