Mouse monoclonal antibody raised against native EGFR.
Native purified EGFR from human epidermoid carcinoma line A431.
Recognizes the (Mr 170KDa) extracellular domain of the epidermal growth factor receptor on many cell surfaces. The EGFR mediates the initial response of cells to EGF. It has an extracellular region, which binds EGF and an intracellular region, which exhibits tyrosine kinase activity. The receptor phosphorylates a number of protein substrates in addition to mediating autophosphorylation of tyrosine residues located near its carboxyl terminus.
Flow Cytometry (using 1ug to stain 1 x 106 cells) The optimal working dilution should be determined by the end user.
In 10 mM PBS, pH 7.4 (1% BSA, 0.09% sodium azide)
Store at 4°C. Do not freeze.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq
avian erythroblastic leukemia viral (v-erb-b) oncogene homolog,cell growth inhibiting protein 40,cell proliferation-inducing protein 61,epidermal growth factor receptor