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Last updated: 2014/9/15
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CD44 monoclonal antibody, clone DF 1485

  • Catalog # : MAB5315
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native CD44.
  • Immunogen:
  • Native purified human CD44.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • HCAM, CD44 is a transmembrane glycoprotein which is expressed by lymphocytes and several normal epithelial cells. The CD44 molecule is involved in lymphocyte homing, T-lymphocyte actvitation, interaction with hyaluronic acid and may act as an adhesion molecule. Standard CD 44 (CD44s) is composed of the products of exons 1-5 a less favourable prognosis in gastrointestinal cancers, the loss of CD44s expression predicts unfavourable outcome in bladder cancers, squamous cell carcinomas of the skin, prostatic adenocarcinomas and neuroblastomas. In immunoblotting this antibody reacts with a glycoprotein isolated from hemopoietic cells and epithelials cells with a respective molecular weight of 29-37 and 51 kD.
  • Form:
  • Liquid
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Immunohistochemistry (1:5-1:10)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In tissue culture supernatant
  • Storage Instruction:
  • Store at 4°C.
  • Applications
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Frozen sections)
  • Application Image
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Frozen sections)
  • Gene Information
  • Entrez GeneID:
  • 960
  • Gene Name:
  • CD44
  • Gene Alias:
  • CDW44,CSPG8,ECMR-III,HCELL,IN,LHR,MC56,MDU2,MDU3,MGC10468,MIC4,MUTCH-I,Pgp1
  • Gene Description:
  • CD44 molecule (Indian blood group)
  • Gene Summary:
  • The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq
  • Other Designations:
  • CD44 antigen,CD44 antigen (homing function and Indian blood group system),CDW44 antigen,GP90 lymphocyte homing/adhesion receptor,Hermes antigen,antigen gp90 homing receptor,cell adhesion molecule,cell surface glycoprotein CD44,chondroitin sulfate proteogl
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