KRT20 monoclonal antibody, clone Ks 20.8
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Specification
Product Description
Mouse monoclonal antibody raised against KRT20.
Immunogen
Human KRT20.
Host
Mouse
Reactivity
Human
Specificity
This antibody is specific to the 46KDa polypeptide (cytokeratin 20). It represents an excellent marker for certain carcinomas such as adenocarcinoma of the colon, transitional cell carcinoma of the bladder and Merkel cell skin tumours. This antibody can be used in the detection of intestinal and gastric foveolar epithelium, urothelial cells and Merkel cells of the epidermis as well as tumours of their origin (e.g. primary and metastatic colorectal cancer). Adenocarcinomas of the breast and lung also neuroendocrine tumours of the lung are essentially negative.
Form
Liquid
Purification
Protein A purification
Concentration
16 ug/mL
Isotype
IgG2a
Recommend Usage
Recommend dilution at 1:20-1:50
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.09% sodium azide, 0.5% BSA)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
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Gene Info — KRT20
Entrez GeneID
54474Gene Name
KRT20
Gene Alias
CD20, CK20, K20, KRT21, MGC35423
Gene Description
keratin 20
Omim ID
608218Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq
Other Designations
cytokeratin 20|keratin, type I cytoskeletal 20
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Interactome
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Disease
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