HLA-A2 monoclonal antibody, clone BB7.2 (PE)
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Specification
Product Description
Mouse monoclonal antibody raised against HLA-A2.
Immunogen
HLA-A2.
Host
Mouse
Reactivity
Human
Specificity
This antibody recognizes an epitope at the C-terminus of alpha-2 helix and a turn on one of the underlying beta strands within the human HLA-A2 histocompatibility antigen.
Form
Liquid
Conjugation
PE
Isotype
IgG2b
Recommend Usage
Flow Cytometry analysis of human blood cells using 20 ul reagent / 100 ul of whole blood or 106 cells in a suspension.
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
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Gene Info — HLA-A
Entrez GeneID
3105Gene Name
HLA-A
Gene Alias
HLAA
Gene Description
major histocompatibility complex, class I, A
Gene Ontology
HyperlinkGene Summary
HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq
Other Designations
HLA class I histocompatibility antigen, A-23 alpha chain|MHC class I antigen HLA-A heavy chain|MHC leukocyte antigen|OTTHUMP00000161059|antigen presenting molecule|leucocyte antigen class I|leukocyte antigen class I-A
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Interactome
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Pathway
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Disease
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Publication Reference
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A simplified PCR-SSP method for HLA-A2 subtype in a population of Wuhan, China.
Liang B, Zhu L, Liang Z, Weng X, Lu X, Zhang C, Li H, Wu X.
Cellular & Molecular Immunology 2006 Dec; 3(6):453.
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Induction of ovarian tumor-specific CD8+ cytotoxic T lymphocytes by acid-eluted peptide-pulsed autologous dendritic cells.
Santin AD, Bellone S, Ravaggi A, Pecorelli S, Cannon MJ, Parham GP.
Obstetrics and Gynecology 2000 Sep; 96(3):422.
Application:Incubated, Recombinant protein.
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Isolation of broadly reactive, tumor-specific, HLA Class-I restricted CTL from blood lymphocytes of a breast cancer patient.
Verdegaal EM, Huinink DB, Hoogstraten C, Marijnissen AK, Gorsira MB, Claas FH, Osanto S.
Human Immunology 1999 Dec; 60(12):1195.
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Juvenile arthritis, HLA-A2 and binding of DEK oncogene-peptides.
Forero L, Zwirner NW, Fink CW, Fernandez-Vina MA, Stastny P.
Human Immunology 1998 Jul; 59(7):443.
Application:Flow Cyt, Human, T2 cells.
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A recombinant single-chain HLA-A2.1 molecule, with a cis active beta-2-microglobulin domain, is biologically active in peptide binding and antigen presentation.
Lee L, Loftus D, Appella E, Margulies DH, Mage M.
Human Immunology 1996 Aug; 49(1):28.
Application:Flow Cyt, Func, Human, KJ29, KJ29.β2m, KJ29.MSCβA2.1.
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A simplified PCR-SSP method for HLA-A2 subtype in a population of Wuhan, China.
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