TNFRSF10D monoclonal antibody, clone TRAIL-R4-01 (PE)
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant TNFRSF10D.
Immunogen
Recombinant Fc fusion protein corresponding to amino acids 1-210 of TNFRSF10D.
Host
Mouse
Theoretical MW (kDa)
42
Reactivity
Human
Specificity
This antibody reacts with TRAIL-R4, a 42 KDa transmembrane protein expressed on various blood cells.
Form
Liquid
Conjugation
PE
Concentration
0.1 mg/mL
Isotype
IgG1
Recommend Usage
Flow Cytometry (3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
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Gene Info — TNFRSF10D
Entrez GeneID
8793Gene Name
TNFRSF10D
Gene Alias
CD264, DCR2, TRAILR4, TRUNDD
Gene Description
tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
Omim ID
603614Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. [provided by RefSeq
Other Designations
TNF receptor-related receptor for TRAIL|TRAIL receptor 4|TRAIL receptor with a truncated death domain|decoy receptor 2|decoy with truncated death domain|tumor necrosis factor receptor superfamily, member 10d
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Interactome
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Pathway
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Disease
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Publication Reference
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Expression of the TRAIL receptors in blood mononuclear cells in leukemia.
Deligezer U, Dalay N.
Pathology Oncology Research 2007 Dec; 13(4):290.
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TRAIL signalling: decisions between life and death.
Falschlehner C, Emmerich CH, Gerlach B, Walczak H.
The International Journal of Biochemistry & Cell Biology 2007 Feb; 39(7-8):1462.
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Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2.
Merino D, Lalaoui N, Morizot A, Schneider P, Solary E, Micheau O.
Molecular and Cellular Biology 2006 Oct; 26(19):7046.
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Expression of the TRAIL receptors in blood mononuclear cells in leukemia.
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