SEMA7A monoclonal antibody, clone MEM-150 (FITC)
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More Files
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Flow Cytometry
Surface staining of HPB-ALL (human peripheral blood T cell leukemia cell line) with SEMA7A monoclonal antibody, clone MEM-150 (FITC) (Cat # MAB5051). Total viable cells were used for analysis.
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Specification
Product Description
Mouse monoclonal antibody raised against native SEMA7A.
Immunogen
Native purified SEMA7A from HPB-ALL human T cell line.
Host
Mouse
Theoretical MW (kDa)
80
Reactivity
Human
Specificity
This antibody reacts with CD108 (JMH blood group antigen), a 80 KDa GPI-anchored glycoprotein expressed on various cell types including erythrocytes, lymphoblasts; at low levels it is present on circulating lymphocytes.
Form
Liquid
Conjugation
FITC
Isotype
IgM
Recommend Usage
Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Surface staining of HPB-ALL (human peripheral blood T cell leukemia cell line) with SEMA7A monoclonal antibody, clone MEM-150 (FITC) (Cat # MAB5051). Total viable cells were used for analysis. -
Gene Info — SEMA7A
Entrez GeneID
8482Gene Name
SEMA7A
Gene Alias
CD108, CDw108, H-SEMA-K1, H-Sema-L, JMH, MGC126692, MGC126696, SEMAK1, SEMAL
Gene Description
semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
Omim ID
607961Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene binds to cell surfaces through a glycosylphosphatidylinositol (GPI) linkage. The encoded glycoprotein is found on activated lymphocytes and erythrocytes. This protein may be involved in immunomodulatory and neuronal processes. Defects in this gene can result in loss of bone mineral density (BMD). Three transcript variants encoding different isoforms have been found for this gene
Other Designations
John Milton Hagen blood group H-Sema K1|sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A (JMH blood group)|sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, 7A|semaphorin 7A|semaphorin K1|semaphorin L
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Interactome
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Pathway
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Disease
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Publication Reference
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Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin.
Suzuki K, Okuno T, Yamamoto M, Pasterkamp RJ, Takegahara N, Takamatsu H, Kitao T, Takagi J, Rennert PD, Kolodkin AL, Kumanogoh A, Kikutani H.
Nature 2007 Apr; 446(7136):680.
Application：IF, Mouse, Mouse bone-marrow-derived macrophages.
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Characterization of the human leukocyte GPI-anchored glycoprotein CDw108 and its relation to other similar molecules.
Angelisova P, Drbal K, Cerny J, Hilgert I, Horejsi V.
Immunobiology 1999 Jun; 200(2):234.
Application：Flow Cyt, Human, Human lymphocytes.
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Evidence that CDw108 membrane protein bears the JMH blood group antigen.
Mudad R, Rao N, Angelisova P, Horejsi V, Telen MJ.
Transfusion 1995 Jul; 35(7):566.
Application：Func, RIA, WB-Ce, Human, Antibodies, Human red blood cells.
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Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin.
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