B cell activation antigen B7-1 is also called BB1 and clustered as CD80 during the 5th Leucocyte Typing workshop. CD80 is a member of the Ig superfamily and serves as the ligand for two T-cell molecules, CD28 and CD152 (CTLA-4). Reacts with in vitro activated normal B cells. Reacts weakly with a small proportion of non-activated normal B cells. Does not react with peripheral monocytes, resting and activated normal T cells, T-cell lines and T-cell clones. The molecular weight of the recognized antigen is 60KDa.
Immunofluorescence (2ug/5x105 cells/test) Flow Cytometry (2ug/5x105 cells/test) Immunohistochemistry (Frozen sections)(1:20-1:50) The optimal working dilution should be determined by the end user.
Lyophilized from PBS (1mg/mL BSA)
Store at 4°C on dry atmosphere. After reconstitution with deionized water, store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
The B-lymphocyte activation antigen B7-1 (formerly referred to as B7) provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 (MIM 186760) and CTLA4 (MIM 123890) ligands of T cells.[supplied by OMIM