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Amyloid-beta monoclonal antibody, clone 2H4

  • Catalog # : MAB4650
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against Amyloid-beta.
  • Immunogen:
  • Amino acids 1-24 (NAEFRHDSGYQVHHQKLVFFAEDV) of Beta amyloid.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • Reactive to the amino terminal region (a.a. residues 1-8) of human beta Amyloid peptide. Highly reactive to Amyloid beta form of APP.
  • Form:
  • Liquid
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Dot Blot (1:100-1:1000)
    Immunohistochemistry (1:100-1:1000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Publication Reference
  • Applications
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Frozen sections)
  • Application Image
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Frozen sections)
  • Gene Information
  • Entrez GeneID:
  • 351
  • Gene Name:
  • APP
  • Gene Alias:
  • AAA,ABETA,ABPP,AD1,APPI,CTFgamma,CVAP,PN2
  • Gene Description:
  • amyloid beta (A4) precursor protein
  • Gene Summary:
  • This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • A4 amyloid protein,amyloid beta A4 protein,amyloid-beta protein,beta-amyloid peptide,cerebral vascular amyloid peptide,peptidase nexin-II,protease nexin-II
  • Interactome
  • Gene Pathway
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