KRT19 monoclonal antibody, clone BA-17 (Biotin)
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Specification
Product Description
Mouse monoclonal antibody raised against native KRT19.
Immunogen
Native purified KRT19 from mammary organoids.
Host
Mouse
Theoretical MW (kDa)
40
Reactivity
Human
Specificity
This antibody reacts with cytokeratin 19 (40 KDa) in human tissue.
Form
Liquid
Conjugation
Biotin
Concentration
1 mg/mL
Isotype
IgG1
Recommend Usage
Western Blot (2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
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Gene Info — KRT19
Entrez GeneID
3880Gene Name
KRT19
Gene Alias
CK19, K19, K1CS, MGC15366
Gene Description
keratin 19
Omim ID
148020Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq
Other Designations
40-kDa keratin intermediate filament|cytokeratin 19|keratin, type I cytoskeletal 19|keratin, type I, 40-kd
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Interactome
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Disease
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Publication Reference
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The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer.
Lewis BC, Klimstra DS, Varmus HE.
Genes & Development 2003 Dec; 17(24):3127.
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Patterns of expression of keratin 19 as detected with monoclonal antibodies in human breast tissues and tumours.
Bartek J, Taylor-Papadimitriou J, Miller N, Millis R.
International Journal of Cancer 1985 Sep; 36(3):299.
Application：IHC-Fr, IHC-P, WB-Ti, Human, Human breast tumors.
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A subclass of luminal epithelial cells in the human mammary gland, defined by antibodies to cytokeratins.
Bartek J, Durban EM, Hallowes RC, Taylor-Papadimitriou J.
Journal of Cell Science 1985 Apr; 75:17.
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The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer.
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