CD1A monoclonal antibody, clone HI149 (PE)
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Specification
Product Description
Mouse monoclonal antibody raised against native CD1A.
Immunogen
Native purified CD1A from human thymocytes.
Host
Mouse
Reactivity
Human
Specificity
This antibody reacts with CD1a (T6), a 49 KDa polypeptide associated with beta 2-microglobulin expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells and some T cell leukemias and lymphomas.
This antibody does not react with peripheral blood T and B lymphocytes, monocytes, granulocytes, platelets and erythrocytes.Form
Liquid
Conjugation
PE
Isotype
IgG1
Recommend Usage
Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Frozen sections)
Flow Cytometry
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Gene Info — CD1A
Entrez GeneID
909Gene Name
CD1A
Gene Alias
CD1, FCB6, HTA1, R4, T6
Gene Description
CD1a molecule
Omim ID
188370Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq
Other Designations
CD1A antigen|CD1A antigen, a polypeptide|OTTHUMP00000018907|T-cell surface antigen T6/Leu-6|T-cell surface glycoprotein CD1a|cluster of differentiation 1 A|cortical thymocyte antigen CD1A|differentiation antigen CD1-alpha-3|epidermal dendritic cell marker
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Interactome
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Pathway
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Publication Reference
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CD1 antigen presentation by human dendritic cells as a target for herpes simplex virus immune evasion.
Raftery MJ, Winau F, Kaufmann SH, Schaible UE, Schönrich G.
Journal of Immunology 2006 Nov; 177(9):6207.
Application：Flow Cyt, Human, DC, U373 cells.
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Characterization of guinea-pig group 1 CD1 proteins.
Hiromatsu K, Dascher CC, Sugita M, Gingrich-Baker C, Behar SM, LeClair KP, Brenner MB, Porcelli SA.
Immunology 2002 Jun; 106(2):159.
Application：Flow Cyt, Mouse, 104C1 cells.
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Separate pathways for antigen presentation by CD1 molecules.
Sugita M, Grant EP, van Donselaar E, Hsu VW, Rogers RA, Peters PJ, Brenner MB.
Immunity 1999 Dec; 11(6):743.
Application：IEM, IF, Human, HeLa cells, Human dendritic cells, Human epidermal langerhans cells, Human skin.
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CD1 antigen presentation by human dendritic cells as a target for herpes simplex virus immune evasion.
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