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Last updated: 2014/8/25
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CD1A monoclonal antibody, clone HI149 (PE)

  • Catalog # : MAB4378
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native CD1A.
  • Immunogen:
  • Native purified CD1A from human thymocytes.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • This antibody reacts with CD1a (T6), a 49 KDa polypeptide associated with beta 2-microglobulin expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells and some T cell leukemias and lymphomas.
    This antibody does not react with peripheral blood T and B lymphocytes, monocytes, granulocytes, platelets and erythrocytes.
  • Form:
  • Liquid
  • Conjugation:
  • PE
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.2% BSA, 15 mM sodium azide)
  • Storage Instruction:
  • Store in the dark at 4°C. Do not freeze.
    Avoid prolonged exposure to light.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Immunohistochemistry (Frozen sections)
  • Flow Cytometry
  • Application Image
  • Immunohistochemistry (Frozen sections)
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 909
  • Gene Name:
  • CD1A
  • Gene Alias:
  • CD1,FCB6,HTA1,R4,T6
  • Gene Description:
  • CD1a molecule
  • Gene Summary:
  • This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq
  • Other Designations:
  • CD1A antigen,CD1A antigen, a polypeptide,OTTHUMP00000018907,T-cell surface antigen T6/Leu-6,T-cell surface glycoprotein CD1a,cluster of differentiation 1 A,cortical thymocyte antigen CD1A,differentiation antigen CD1-alpha-3,epidermal dendritic cell marker
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