Mouse monoclonal antibody raised against synthetic peptide of Amyloid-beta 1-40.
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human Amyloid-beta 1-40.
Specifically reacts with the C-terminus of human beta Amyloid 1-40. Does not cross-react with beta Amyloid 1-42.
ELISA (0.1 ug/mL) Western Blot (1 ug/mL HRP/ECL detection) Immunocytochemistry (1-10 ug/mL) The optimal working dilution should be determined by the end user.
Lyophilized from 2x PBS (PEG, sucrose, 0.09% sodium azide)
Store at -20°C on dry atmosphere. After reconstitution with deionized water, store at -80°C or lower. Aliquot to avoid repeated freezing and thawing.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Western blot analysis of Beta amyloid peptides were applied to SDS-PAGE and transferred to a PVDF membrane. The blot was probed with 2 ug/mL Beta amyloid monoclonal antibody, clone BDI350 (Cat # MAB3913) for 1 hour at 15-22°C and developed by ECL. Lane 1 : Beta amyloid (1-40). Lane 2 : Beta amyloid (1-42). Lane 3 : Beta amyloid (1-43).
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq