CD300A monoclonal antibody, clone MEM-260
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More Files
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Flow Cytometry
Surface staining of human peripheral blood cells with CD300A monoclonal antibody, clone MEM-260 (Cat # MAB3834) - PE.
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Specification
Product Description
Mouse monoclonal antibody raised against native CD300A.
Immunogen
Native purified CD300A from human HPB acute lymphoid leukaemia cell line.
Host
Mouse
Theoretical MW (kDa)
60
Reactivity
Human
Specificity
This antibody reacts with CD300a, a 60 KDa leukocyte transmembrane glycoprotein expressed on human granulocytes, monocytes, neutrophils, NK cells, mast cells and dendritic cells, 25% of circulating T cells and 15% of circulating B cells.
Form
Liquid
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS, pH 7.4 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Flow Cytometry
Surface staining of human peripheral blood cells with CD300A monoclonal antibody, clone MEM-260 (Cat # MAB3834) - PE. -
Gene Info — CD300A
Entrez GeneID
11314Gene Name
CD300A
Gene Alias
CMRF-35-H9, CMRF-35H, CMRF35H, CMRF35H9, IGSF12, IRC1, IRC2, IRp60
Gene Description
CD300a molecule
Omim ID
606790Gene Ontology
HyperlinkGene Summary
The CMRF35 antigen (CMRF35A; MIM 606786), which was identified by reactivity with a monoclonal antibody, is present on monocytes, neutrophils, and some T and B lymphocytes. CMRF35H is recognized by the same antibody and is distinct from CMRF35 (Green et al., 1998 [PubMed 9701027]).[supplied by OMIM
Other Designations
CD300a antigen|CMRF35H leukocyte immunoglobulin-like receptor|leukocyte membrane antigen
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Interactome
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Publication Reference
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The CD300a (IRp60) inhibitory receptor is rapidly up-regulated on human neutrophils in response to inflammatory stimuli and modulates CD32a (FcgammaRIIa) mediated signaling.
Alvarez Y, Tang X, Coligan JE, Borrego F.
Molecular Immunology 2008 Jan; 45(1):253.
Application：Flow Cyt, Human, HL-60 cells, Human neutrophils.
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Molecular analysis and solution structure from small-angle X-ray scattering of the human natural killer inhibitory receptor IRp60 (CD300a).
Dimasi N, Roessle M, Moran O, Candiano G, Svergun DI, Biassoni R.
International Journal of Biological Macromolecules 2007 Feb; 40(3):193.
Application：IF, Recombinant protein.
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Abrogation of allergic reactions by a bispecific antibody fragment linking IgE to CD300a.
Bachelet I, Munitz A, Levi-Schaffer F.
The Journal of Allergy and Clinical Immunology 2006 Jun; 117(6):1314.
Application：Flow Cyt, Rat, RBL cells.
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The CD300a (IRp60) inhibitory receptor is rapidly up-regulated on human neutrophils in response to inflammatory stimuli and modulates CD32a (FcgammaRIIa) mediated signaling.
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