SERPINE1 (inhibitory) monoclonal antibody
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Specification
Product Description
Mouse monoclonal antibody raised against SERPINE1 (inhibitory).
Immunogen
Human SERPINE1.
Host
Mouse
Reactivity
Human, Rabbit
Specificity
This purified monoclonal antibody, made against human PAI-1, is inhibitory through the binding of a epitope on PAI-1 creating the latent form.
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In 50 mM sodium phosphate buffer, 100 mM NaCl, pH 7.4
Storage Instruction
Store at -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Enzyme-linked Immunoabsorbent Assay
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Gene Info — SERPINE1
Entrez GeneID
5054Gene Name
SERPINE1
Gene Alias
PAI, PAI-1, PAI1, PLANH1
Gene Description
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Omim ID
173360Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
plasminogen activator inhibitor, type I|plasminogen activator inhibitor-1|serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Elucidation of the epitope of a latency-inducing antibody: identification of a new molecular target for PAI-1 inhibition.
Naessens D, Gils A, Compernolle G, Declerck PJ.
Thrombosis and Haemostasis 2003 Jul; 90(1):52.
Application:ELISA, Func, Recombinant protein.
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Mapping of a conformational epitope on plasminogen activator inhibitor-1 by random mutagenesis. Implications for serpin function.
Gorlatova NV, Elokdah H, Fan K, Crandall DL, Lawrence DA.
The Journal of Biological Chemistry 2003 May; 278(18):16329.
Application:Func, WB, Bacteria, Bacteria.
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Neutralization of plasminogen activator inhibitor-1 inhibitory properties: identification of two different mechanisms.
Debrock S, Declerck PJ.
Biochimica et Biophysica Acta 1997 Feb; 1337(2):257.
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Elucidation of the epitope of a latency-inducing antibody: identification of a new molecular target for PAI-1 inhibition.
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