TLR3 monoclonal antibody, clone 40C1285
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More Files
- More Functions
Western Blot (Transfected lysate)
Western blot analysis of TLR3 in lysates from untransfected 293 cells (lane A), 293 cells transfected with human TLR3 cDNA (lane B), and 20 ug/lane human intestine tissue lysate (lane C).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of human gut lumen (longitudinal section, transverse region) using TLR3 monoclonal antibody, clone 40C1285 (Cat # MAB3706) at 10 ug/mL .
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of TLR3.
Immunogen
A synthetic peptide corresponding to cytoplasmic portion of human TLR3.
Host
Mouse
Reactivity
Human, Mouse
Specificity
Recognizes human Toll-like Receptor 3 (TLR3).
Form
Liquid
Isotype
IgG1
Recommend Usage
Immunoprecipitation (2 ug/106 cells)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis of TLR3 in lysates from untransfected 293 cells (lane A), 293 cells transfected with human TLR3 cDNA (lane B), and 20 ug/lane human intestine tissue lysate (lane C).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of human gut lumen (longitudinal section, transverse region) using TLR3 monoclonal antibody, clone 40C1285 (Cat # MAB3706) at 10 ug/mL .Immunocytochemistry
Immunoprecipitation
Flow Cytometry
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Gene Info — TLR3
Entrez GeneID
7098Gene Name
TLR3
Gene Alias
CD283
Gene Description
toll-like receptor 3
Omim ID
603029Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq
Other Designations
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Interactome
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Pathway
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Disease
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