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PTPRC monoclonal antibody, clone 2B11/PD7/26   

  • Catalog # : MAB3508
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  • 1 mL
  • USD $ 319
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native PTPRC.
  • Immunogen:
  • Native purified PTPRC from activated and neoblastic T-cells.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • This antibody reacts with cell membrane of lymphoid cells (macrophages and polymorph nuclear lymphocytes stain weakly, while plasma cells usually are negative). No reactivity with non-haematopoietic cells, epithelia and connective tissue.
  • Form:
  • Liquid
  • Concentration:
  • 30 ug/mL
  • Isotype:
  • IgG2b
  • Recommend Usage:
  • Immunohistochemistry (1:10-1:50)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.3 (BSA, 0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. Do not freeze.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Frozen sections)
  • Flow Cytometry
  • Application Image
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Frozen sections)
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 5788
  • Gene Name:
  • PTPRC
  • Gene Alias:
  • B220,CD45,CD45R,GP180,LCA,LY5,T200
  • Gene Description:
  • protein tyrosine phosphatase, receptor type, C
  • Gene Summary:
  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq
  • Other Designations:
  • CD45 antigen,T200 glycoprotein,T200 leukocyte common antigen,glycoprotein,leukocyte-common antigen,protein tyrosine phosphatase, receptor type, c polypeptide
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