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CTSB monoclonal antibody, clone CB131

  • Catalog # : MAB3494
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against full length recombinant CTSB.
  • Immunogen:
  • Recombinant protein corresponding to full length human CTSB.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Form:
  • Lyophilized
  • Isotype:
  • IgG2b
  • Recommend Usage:
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:40-1:80)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • Lyophilized from tissue culture supernatant (15 mM sodium azide)
  • Storage Instruction:
  • Store at 4°C on dry atmosphere.
    After reconstitution with distilled water, store at -20°C or lower.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Application Image
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Gene Information
  • Entrez GeneID:
  • 1508
  • Gene Name:
  • CTSB
  • Gene Alias:
  • APPS,CPSB
  • Gene Description:
  • cathepsin B
  • Gene Summary:
  • The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
  • Other Designations:
  • APP secretase,OTTHUMP00000116009,amyloid precursor protein secretase,cathepsin B1,cysteine protease,preprocathepsin B
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