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APAF1 monoclonal antibody, clone 2E12

  • Catalog # : MAB3406
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  • Specification
  • Product Description:
  • Rat monoclonal antibody raised against partial recombinant APAF1.
  • Immunogen:
  • Recombinant Flag fusion protein corresponding to amino acids 1-464 of human APAF1.
  • Host:
  • Rat
  • Reactivity:
  • Human
  • Specificity:
  • Recognizes the CARD domain of human Apaf-1. Does not cross-react with mouse or rat Apaf-1.
  • Form:
  • Liquid
  • Isotype:
  • IgG2a
  • Recommend Usage:
  • The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.02% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot
  • Immunohistochemistry (Frozen sections)
  • Immunocytochemistry
  • Immunoprecipitation
  • ELISA
  • Application Image
  • Western Blot
  • Immunohistochemistry (Frozen sections)
  • Immunocytochemistry
  • Immunoprecipitation
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 317
  • Gene Name:
  • APAF1
  • Gene Alias:
  • CED4,DKFZp781B1145
  • Gene Description:
  • apoptotic peptidase activating factor 1
  • Gene Summary:
  • This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq
  • Other Designations:
  • apoptotic protease activating factor 1
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