ABCC4 monoclonal antibody, clone M4I-10
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Specification
Product Description
Rat monoclonal antibody raised against recombinant ABCC4.
Immunogen
Recombinant protein corresponding to chimeric protein with amino acids 372-431 of human ABCC4 and bacterial maltose-binding protein.
Host
Rat
Reactivity
Human, Mouse
Specificity
MRP4 transports cyclic nucleotides and anti-retroviral compounds. Anti-MRP4 clone M4I-10 reacts with human multidrug resistance protein 4 as well as with the mouse orthologue of the transporter molecule (Mrp4).
Form
Liquid
Isotype
IgG2a
Recommend Usage
Immunohistochemistry (Frozen sections) (1:20)
Immunocytochemistry (1:20-1:50)
Western Blot (1:20-1:50)
The optimal working dilution should be determined by the end user.Storage Buffer
In serum-free culture supernatant (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Frozen sections)
Immunocytochemistry
Flow Cytometry
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Gene Info — ABCC4
Entrez GeneID
10257Gene Name
ABCC4
Gene Alias
EST170205, MOAT-B, MOATB, MRP4
Gene Description
ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Omim ID
605250Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions. Alternative splicing results in multiple splice variants encoding different isoforms. [provided by RefSeq
Other Designations
ATP-binding cassette, sub-family C, member 4|OTTHUMP00000018560|bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4)|canalicular multispecific organic anion transporter (ABC superfamily)|multidrug resistance-associated protein 4|multispecif
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Interactome
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Pathway
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Disease
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