EGFR monoclonal antibody, clone SB41a
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More Files
- More Functions
Western Blot (Cell lysate)
HT-29 cell lysate was used with EGFR monoclonal antibody, clone SB41a (Cat # MAB3323) , 1st lane, and Mouse Anti-EGFR-HRP, 2 nd lane. Goat Anti-Mouse IgG2a was used in conjunction with the unlabeled antibody.
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant EGFR.
Immunogen
Recombinant protein corresponding to human EGFR.
Host
Mouse
Reactivity
Human
Specificity
human EGFR.
Form
Liquid
Isotype
IgG2a
Recommend Usage
Western Blot (1-2 ug/mL)
Immunohistochemistry (10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 100 mM BBS, pH 8.0
Storage Instruction
Store at 4°C.
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Applications
Western Blot (Cell lysate)
HT-29 cell lysate was used with EGFR monoclonal antibody, clone SB41a (Cat # MAB3323) , 1st lane, and Mouse Anti-EGFR-HRP, 2 nd lane. Goat Anti-Mouse IgG2a was used in conjunction with the unlabeled antibody.Immunohistochemistry (Frozen sections)
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Gene Info — EGFR
Entrez GeneID
1956Gene Name
EGFR
Gene Alias
ERBB, ERBB1, HER1, PIG61, mENA
Gene Description
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq
Other Designations
avian erythroblastic leukemia viral (v-erb-b) oncogene homolog|cell growth inhibiting protein 40|cell proliferation-inducing protein 61|epidermal growth factor receptor
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Interactome
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Pathway
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Disease
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Publication Reference
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Cell signaling by receptor tyrosine kinases.
Schlessinger J.
Cell 2000 Oct; 103(2):211.
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Epidermal growth factor receptor tyrosine kinase as a target for anticancer therapy.
Raymond E, Faivre S, Armand JP.
Drugs 2000 Aug; Suppl1:15.
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Kinase inhibitors in cancer therapy: a look ahead.
Sedlacek HH.
Drugs 2000 Mar; 59(3):435.
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Cell signaling by receptor tyrosine kinases.
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