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Last updated: 2014/10/27
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MMP2 monoclonal antibody, clone MMP2/8B4

  • Catalog # : MAB2335
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against recombinant MMP2.
  • Immunogen:
  • Recombinant protein corresponding to human MMP2.
  • Host:
  • Mouse
  • Reactivity:
  • Human, Mouse, Rat
  • Specificity:
  • This antibody is specific to pro and active MMP2.
  • Form:
  • Liquid
  • Isotype:
  • IgG1, kappa
  • Quality Control Testing:
  • Antibody Reactive Against Recombinant Protein.
  • Recommend Usage:
  • ELISA (0.3 ug/mL)
    Western Blot (1-2 ug/mL)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (2 ug/mL)
    Immunohistochemistry (Frozen sections) (2 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.05% sodium azide)
  • Storage Instruction:
  • Store at -20°C or -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Detection of MMP2 staining in formalin-fixed paraffin-embedded human ovary tissue using MMP2 monoclonal antibody, clone MMP2/8B4 (Cat # MAB2335). Primary antibody was used at 2.5 ug/mL with the avidin-biotin-peroxidase detection method.
  • Immunohistochemistry (Frozen sections)
  • Immunoprecipitation
  • ELISA
  • Application Image
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Immunohistochemistry (Frozen sections)
  • Immunoprecipitation
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 4313
  • Gene Name:
  • MMP2
  • Gene Alias:
  • CLG4,CLG4A,MMP-II,MONA,TBE-1
  • Gene Description:
  • matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
  • Gene Summary:
  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • collagenase type IV-A,matrix metalloproteinase 2,matrix metalloproteinase-II,neutrophil gelatinase
  • Interactome
  • Interactome
  • Related Disease
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