POLE3 monoclonal antibody, clone 3C5.1
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of POLE3 in HeLa cell lysate with POLE3 monoclonal antibody (Cat # MAB2307).
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Specification
Product Description
Mouse monoclonal antibody raised against full length native POLE3.
Immunogen
Native purified human POLE3.
Host
Mouse
Reactivity
Human, Mouse, Primates
Specificity
This antibody is specific to the human DNA pol epsilon and does not recognize DNA pol alpha, beta or delta.
Form
Liquid
Isotype
IgG2a
Quality Control Testing
Antibody Reactive Against Native Purified Protein.
Recommend Usage
Western Blot (5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
No additive
Storage Instruction
Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Cell lysate)
Western blot analysis of POLE3 in HeLa cell lysate with POLE3 monoclonal antibody (Cat # MAB2307). -
Gene Info — POLE3
Entrez GeneID
54107Gene Name
POLE3
Gene Alias
CHARAC17, CHRAC17, YBL1, p17
Gene Description
polymerase (DNA directed), epsilon 3 (p17 subunit)
Omim ID
607267Gene Ontology
HyperlinkGene Summary
POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM
Other Designations
DNA polymerase epsilon p17 subunit|DNA polymerase epsilon subunit 3|OTTHUMP00000021954|OTTHUMP00000021955|arsenic transactivated protein|chromatin accessibility complex 17|histone fold protein CHRAC17
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Interactome
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Pathway
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Publication Reference
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Dual mode of interaction of DNA polymerase epsilon with proliferating cell nuclear antigen in primer binding and DNA synthesis.
Maga G, Jonsson ZO, Stucki M, Spadari S, Hubscher U.
Journal of Molecular Biology 1999 Jan; 285(1):259.
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Mammalian base excision repair by DNA polymerases delta and epsilon.
Stucki M, Pascucci B, Parlanti E, Fortini P, Wilson SH, Hubscher U, Dogliotti E.
Oncogene 1998 Aug; 17(7):835.
Application：WB, Recombinant protein.
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Further characterization of HeLa DNA polymerase epsilon.
Chui G, Linn S.
The Journal of Biological Chemistry 1995 Apr; 270(14):7799.
Application：WB-Ce, Human, HeLa cells.
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Dual mode of interaction of DNA polymerase epsilon with proliferating cell nuclear antigen in primer binding and DNA synthesis.
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