NF1 monoclonal antibody, clone McNFn27b
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More Files
- More Functions
Immunohistochemistry
Immunohistochemical staining of NF1 on human dorsal root ganglia with NF1 monoclonal antibody, clone McNFn27b (Cat # MAB2306).
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of NF1.
Immunogen
A synthetic peptide corresponding to amino acids 27-41 of human NF1.
Host
Mouse
Reactivity
Guinea pig, Human, Mouse, Rat
Form
Liquid
Isotype
IgG1, kappa
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Immunohistochemistry (10-20 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide)
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry
Immunohistochemical staining of NF1 on human dorsal root ganglia with NF1 monoclonal antibody, clone McNFn27b (Cat # MAB2306).Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — NF1
Entrez GeneID
4763Gene Name
NF1
Gene Alias
DKFZp686J1293, FLJ21220, NFNS, VRNF, WSS
Gene Description
neurofibromin 1
Gene Ontology
HyperlinkGene Summary
This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq
Other Designations
neurofibromin
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Interactome
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Pathway
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Disease
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Publication Reference
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Protein precoating of elastomeric tissue-engineering scaffolds increased cellularity, enhanced extracellular matrix protein production, and differentially regulated the phenotypes of circulating endothelial progenitor cells.
Sales VL, Engelmayr GC Jr, Johnson JA Jr, Gao J, Wang Y, Sacks MS, Mayer JE Jr.
Circulation 2007 Sep; 116(11 Suppl):I55.
Application：IHC-P, Sheep, EPC-PGS scaffolds.
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Congenital (infantile) pseudarthrosis of the fibula associated with osteofibrous dysplasia.
Hisaoka M, Hashimoto H, Ohguri T, Aoki T, Okamoto S, Tanaka H, Okimoto N, Nakamura T, Ishida T.
Skeletal Radiology 2004 Sep; 33(9):545.
Application：IHC-P, Human, Human peripheral nerve sheath tumors.
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Tumorigenesis in neurofibromatosis: new insights and potential therapies.
Reed N, Gutmann DH.
Trends Mol Med 2001 Apr; 7(4):157.
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Protein precoating of elastomeric tissue-engineering scaffolds increased cellularity, enhanced extracellular matrix protein production, and differentially regulated the phenotypes of circulating endothelial progenitor cells.
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