NF1 monoclonal antibody, clone McNFn27a
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More Files
- More Functions
Western Blot
Western blot analysis of NF1 in Schwann cells from embryonic knockout mice, adult human nerves and neonatal rat nerves with NF1 monoclonal antibody, clone McNFn27a (Cat # MAB2305).
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of NF1.
Immunogen
A synthetic peptide corresponding to amino acids 27-41 of human NF1.
Host
Mouse
Reactivity
Guinea pig, Human, Mouse, Rat
Specificity
This antibody is specific to full-length or truncated forms of neurofibromin.
Form
Liquid
Isotype
IgG1, kappa
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (2-5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide)
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of NF1 in Schwann cells from embryonic knockout mice, adult human nerves and neonatal rat nerves with NF1 monoclonal antibody, clone McNFn27a (Cat # MAB2305).Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — NF1
Entrez GeneID
4763Gene Name
NF1
Gene Alias
DKFZp686J1293, FLJ21220, NFNS, VRNF, WSS
Gene Description
neurofibromin 1
Gene Ontology
HyperlinkGene Summary
This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq
Other Designations
neurofibromin
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Interactome
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Pathway
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Disease
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Publication Reference
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Tumorigenesis in neurofibromatosis: new insights and potential therapies.
Reed N, Gutmann DH.
Trends Mol Med 2001 Apr; 7(4):157.
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Neurofibromin, a tumor suppressor in the nervous system.
Zhu Y, Parada LF.
Experimental Cell Research 2001 Mar; 264(1):19.
Application：IHC, WB, Human, Brains, Malignant peripheral nerve sheath tumors.
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Tumorigenesis in neurofibromatosis: new insights and potential therapies.
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