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Last updated: 2014/11/16
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MUC1 monoclonal antibody, clone SPM493

  • Catalog # : MAB2110
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native MUC1.
  • Immunogen:
  • Native purified MUC1 from human breast cell line ZR-75-1.
  • Host:
  • Mouse
  • Theoretical MW (kDa):
  • 265-400
  • Reactivity:
  • Human
  • Specificity:
  • This antibody stains an underglycosylated MUC1 often present on carcinoma cells and of some extra prognostic significance.
  • Form:
  • Liquid
  • Purification:
  • Protein A purification
  • Concentration:
  • Lot specific
  • Isotype:
  • IgG1, kappa
  • Quality Control Testing:
  • Antibody Reactive Against Native Purified Protein.
  • Recommend Usage:
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (Formalin/PFA-fixed paraffin-embedded sections) (1:100)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 10 mM PBS, pH 7.4 (1% BSA, 0.1% sodium azide)
  • Storage Instruction:
  • Store at 4°C.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining of MUC1 on formalin fixed, paraffin embedded human breast cancer with MUC1 monoclonal antibody, clone SPM493 (Cat # MAB2110).
  • Application Image
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 4582
  • Gene Name:
  • MUC1
  • Gene Alias:
  • CD227,EMA,H23AG,MAM6,PEM,PEMT,PUM
  • Gene Description:
  • mucin 1, cell surface associated
  • Gene Summary:
  • This gene is a member of the mucin family and encodes a membrane bound, glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length nature of only some has been determined. [provided by RefSeq
  • Other Designations:
  • DF3 antigen,H23 antigen,MUC-1/SEC,MUC-1/X,MUC1/ZD,OTTHUMP00000033787,OTTHUMP00000033790,OTTHUMP00000033795,breast carcinoma-associated antigen DF3,episialin,mucin 1,mucin 1, transmembrane,peanut-reactive urinary mucin,polymorphic epithelial mucin,tumor as
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