LEF1 monoclonal antibody, clone 1C3
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Specifications
Product Description
Mouse monoclonal antibody raised against full length recombinant LEF1.
Immunogen
Recombinant protein corresponding to full length LEF1.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
Western blot (1 to 5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis using LEF1 monoclonal antibody, clone 1C3 (Cat # MAB1942) on Cos cells transfected with the indicated proteins. -
Gene Info — LEF1
Entrez GeneID
51176Gene Name
LEF1
Gene Alias
DKFZp586H0919, TCF1ALPHA
Gene Description
lymphoid enhancer-binding factor 1
Omim ID
153245Gene Ontology
HyperlinkGene Summary
LEF1 is a nuclear protein that is expressed in pre-B and T cells. It binds to a functionally important site in the T-cell receptor-alpha (TCRA; MIM 186880) enhancer and confers maximal enhancer activity. LEF1 belongs to a family of regulatory proteins that share homology with high mobility group protein-1 (HMG1; MIM 163905) (Waterman et al., 1991 [PubMed 2010090]; van Genderen et al., 1994 [PubMed 7958926]).[supplied by OMIM
Other Designations
lymphoid enhancer binding factor-1
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Interactomes
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Pathways
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Diseases
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Publication Reference
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The human LEF-1 gene contains a promoter preferentially active in lymphocytes and encodes multiple isoforms derived from alternative splicing.
Hovanes K, Li TW, Waterman ML.
Nucleic Acids Research 2000 May; 28(9):1994.
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Functional analysis of DNA bending and unwinding by the high mobility group domain of LEF-1.
Giese K, Pagel J, Grosschedl R.
PNAS 1997 Nov; 94(24):12845.
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LEF-1, a nuclear factor coordinating signaling inputs from wingless and decapentaplegic.
Riese J, Yu X, Munnerlyn A, Eresh S, Hsu SC, Grosschedl R, Bienz M.
Cell 1997 Mar; 88(6):777.
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The human LEF-1 gene contains a promoter preferentially active in lymphocytes and encodes multiple isoforms derived from alternative splicing.
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