BCL2L1 monoclonal antibody, clone 2H12
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of BCL2L1 expression in thymocytes from human (lane 1) mouse (lane 2) and rat (lane 3). Using BCL2L1 monoclonal antibody, clone 2H12 (Cat # MAB1802).
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of BCL2L1.
Immunogen
A synthetic peptide corresponding to amino acids 3-14 of human BCL2L1.
Host
Mouse
Reactivity
Human, Mouse, Rat
Form
Liquid
Isotype
IgG2a
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1-5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Tissue lysate)
Western blot analysis of BCL2L1 expression in thymocytes from human (lane 1) mouse (lane 2) and rat (lane 3). Using BCL2L1 monoclonal antibody, clone 2H12 (Cat # MAB1802). -
Gene Info — BCL2L1
Entrez GeneID
598Gene Name
BCL2L1
Gene Alias
BCL-XL/S, BCL2L, BCLX, Bcl-X, DKFZp781P2092, bcl-xL, bcl-xS
Gene Description
BCL2-like 1
Omim ID
600039Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq
Other Designations
OTTHUMP00000030550|OTTHUMP00000030551|OTTHUMP00000030553
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Interactome
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Pathway
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Disease
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Publication Reference
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Nonionic detergents induce dimerization among members of the Bcl-2 family.
Hsu YT, Youle RJ.
The Journal of Biological Chemistry 1997 May; 272(21):13829.
Application：IP, WB-Ce, Human, Mouse, Human and Mouse thymocytes.
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Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis.
Hsu YT, Wolter KG, Youle RJ.
PNAS 1997 Apr; 94(8):3668.
Application：WB-Ce, Mouse, Thymocytes.
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bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death.
Boise LH, González-García M, Postema CE, Ding L, Lindsten T, Turka LA, Mao X, Nuñez G, Thompson CB.
Cell 1993 Aug; 74(4):597.
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Nonionic detergents induce dimerization among members of the Bcl-2 family.
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