BSG monoclonal antibody, clone 2G2
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Specification
Product Description
Mouse monoclonal antibody raised against native BSG.
Immunogen
Native purified from human cancer cel line.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1, kappa
Quality Control Testing
Antibody Reactive Against BSG.
Recommend Usage
Flow Cyt (0.5-1 ug/mL)
Immunoprecipitation (5-10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.1% proclin, 2.0% Block Ace)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunoprecipitation
Flow Cytometry
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Gene Info — BSG
Entrez GeneID
682Gene Name
BSG
Gene Alias
5F7, CD147, EMMPRIN, M6, OK, TCSF
Gene Description
basigin (Ok blood group)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
CD147 antigen|M6 leukocyte activation antigen|OK blood group antigen|basigin|collagenase stimulatory factor|extracellular matrix metalloproteinase inducer
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Interactome
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Disease
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Publication Reference
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Tumor vesicle-associated CD147 modulates the angiogenic capability of endothelial cells.
Millimaggi D, Mari M, D'Ascenzo S, Carosa E, Jannini EA, Zucker S, Carta G, Pavan A, Dolo V.
Neoplasia 2007 Apr; 9(4):349.
Application:Flow Cyt, WB-Ce, Human, A2780, CABAI, HUVECs, OVCAR3, SKOV3 cells.
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Roles of CD147 on T lymphocytes activation and MMP-9 secretion in systemic lupus erythematosus.
Pistol G, Matache C, Calugaru A, Stavaru C, Tanaseanu S, Ionescu R, Dumitrache S, Stefanescu M.
Journal of Cellular and Molecular Medicine 2007 Mar; 11(2):339.
Application:WB, Human, PBMCs.
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A small interfering CD147-targeting RNA inhibited the proliferation, invasiveness, and metastatic activity of malignant melanoma.
Chen X, Lin J, Kanekura T, Su J, Lin W, Xie H, Wu Y, Li J, Chen M, Chang J.
Cancer Research 2006 Dec; 66(23):11323.
Application:WB-Tr, Human, A-375 cells.
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Membrane type 1 matrix metalloproteinase (MT1-MMP/MMP-14) cleaves and releases a 22-kDa extracellular matrix metalloproteinase inducer (EMMPRIN) fragment from tumor cells.
Egawa N, Koshikawa N, Tomari T, Nabeshima K, Isobe T, Seiki M.
The Journal of Biological Chemistry 2006 Dec; 281(49):37576.
Application:Flow Cyt, IHC, WB, Human, A431, HT1080, TMK-1 cells, ovarian carcinoma tissues.
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Regulation of vascular endothelial growth factor expression by EMMPRIN via the PI3K-Akt signaling pathway.
Tang Y, Nakada MT, Rafferty P, Laraio J, McCabe FL, Millar H, Cunningham M, Snyder LA, Bugelski P, Yan L.
Molecular Cancer Research 2006 Jun; 4(6):371.
Application:Func, Human, Human lung fibroblasts.
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Tumor vesicle-associated CD147 modulates the angiogenic capability of endothelial cells.
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