FCAR monoclonal antibody, clone MIP8a
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant FCAR.
Immunogen
Recombinant protein corresponding to extracellular reagion of human FCAR.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
Flow Cytometry (1 ug/100 ul)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunofluorescence
Flow Cytometry
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Gene Info — FCAR
Entrez GeneID
2204Gene Name
FCAR
Gene Alias
CD89
Gene Description
Fc fragment of IgA, receptor for
Omim ID
147045Gene Ontology
HyperlinkGene Summary
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq
Other Designations
Fc alpha receptor|IgA Fc receptor|OTTHUMP00000068692|OTTHUMP00000068696|OTTHUMP00000068697|OTTHUMP00000068698
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Interactome
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Disease
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Publication Reference
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Intracellular pools of FcalphaR (CD89) in human neutrophils are localized in tertiary granules and secretory vesicles, and two FcalphaR isoforms are found in tertiary granules.
Yin N, Peng M, Xing Y, Zhang W.
Journal of Leukocyte Biology 2007 Sep; 82(3):551.
Application:IF, WB-Ce, Human, Neutrophils.
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Neutrophil lactoferrin release induced by IgA immune complexes differed from that induced by cross-linking of fcalpha receptors (FcalphaR) with a monoclonal antibody, MIP8a.
Zhang W, Bi B, Oldroyd RG, Lachmann PJ.
Clinical and Experimental Immunology 2000 Jul; 121(1):106.
Application:ELISA, Flow Cyt, WB-Ce, Human, Mouse, Neutrophils, U937 cells.
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Intracellular pools of FcalphaR (CD89) in human neutrophils are localized in tertiary granules and secretory vesicles, and two FcalphaR isoforms are found in tertiary granules.
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