ESR1 monoclonal antibody, clone S21-V
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human breast tumor tissue (4 um) stained with ESR1 monoclonal antibody, clone S21-V (Cat # MAB1658) shows strong positive nuclear immunostaining. Kindly performed and provided by Katarina Poliakova, MD and Lubomir Straka, MD, Ph. D., from Clinical Pathology Presov, Ltd., Presov, Slovakia.
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic peptide of ESR1.
Immunogen
A synthetic peptide corresponding to C-terminus of human ESR1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Isotype
IgG
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:100)
The optimal working dilution should be determined by the end user.Storage Buffer
In 20 mM Tris-HCl, pH 8.0 (20 mg/mL BSA, 0.05% sodium azide)
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human breast tumor tissue (4 um) stained with ESR1 monoclonal antibody, clone S21-V (Cat # MAB1658) shows strong positive nuclear immunostaining. Kindly performed and provided by Katarina Poliakova, MD and Lubomir Straka, MD, Ph. D., from Clinical Pathology Presov, Ltd., Presov, Slovakia. -
Gene Info — ESR1
Entrez GeneID
2099Gene Name
ESR1
Gene Alias
DKFZp686N23123, ER, ESR, ESRA, Era, NR3A1
Gene Description
estrogen receptor 1
Gene Ontology
HyperlinkGene Summary
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters. [provided by RefSeq
Other Designations
OTTHUMP00000017718|OTTHUMP00000017719|estrogen receptor alpha
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Interactome
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Disease
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