INS monoclonal antibody, clone K36AC10
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Specification
Product Description
Mouse monoclonal antibody raised against native INS.
Immunogen
Native purified human INS.
Host
Mouse
Reactivity
Human, Mouse, Rat
Form
Lyophilized
Purification
Affinity purification
Isotype
IgG1
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.4-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 1.2% sodium acetate (2 mg BSA, 0.01 mg sodium azide)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 1 mL of 1.2% sodium acetate or neutral PBS and concentration will be 100 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
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Gene Info — INS
Entrez GeneID
3630Gene Name
INS
Gene Alias
ILPR, IRDN
Gene Description
insulin
Gene Ontology
HyperlinkGene Summary
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds. Binding of this mature form of insulin to the insulin receptor (INSR) stimulates glucose uptake. A variety of mutant alleles with changes in the coding region have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. [provided by RefSeq
Other Designations
OTTHUMP00000011161|OTTHUMP00000011162|OTTHUMP00000196038|proinsulin
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Interactome
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Pathway
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Disease
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Publication Reference
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Frizzled3 Shapes the Development of Retinal Rod Bipolar Cells.
Shen N, Qu Y, Yu Y, So KF, Goffinet AM, Vardi N, Xu Y, Zhou L.
Investigative Ophthalmology & Visual Science 2016 May; 57(6):2788.
Application:IF, Mouse, Retinal.
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Localization of the human insulin gene to the distal end of the short arm of chromosome 11.
Harper ME, Ullrich A, Saunders GF.
PNAS 1981 Jul; 78(7):4458.
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The insulin gene is located on chromosome 11 in humans.
Owerbach D, Bell GI, Rutter WJ, Shows TB.
Nature 1980 Jul; 286(5768):82.
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Frizzled3 Shapes the Development of Retinal Rod Bipolar Cells.
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