CTSL1 monoclonal antibody, clone 33/2
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Specification
Product Description
Mouse monoclonal antibody raised against native CTSL1.
Immunogen
Native purified human CTSL1.
Host
Mouse
Theoretical MW (kDa)
37.5
Reactivity
Human, Mouse, Rat
Form
Lyophilized
Purification
Affinity purification
Isotype
IgG1
Recommend Usage
Western Blot (2 ug/mL)
Immunohistochemistry (Frozen sections) (4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 1.2% sodium acetate (2 mg BSA, 0.01 mg sodium azide)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 1 mL of 1.2% sodium acetate or neutral PBS and concentration will be 100 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Frozen sections)
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Gene Info — CTSL1
Entrez GeneID
1514Gene Name
CTSL1
Gene Alias
CATL, CTSL, FLJ31037, MEP
Gene Description
cathepsin L1
Omim ID
116880Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. At least two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000021601|OTTHUMP00000021602|OTTHUMP00000063566|cathepsin L|major excreted protein
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Interactome
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Pathway
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Publication Reference
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Cathepsin L is required for endothelial progenitor cell-induced neovascularization.
Urbich C, Heeschen C, Aicher A, Sasaki K, Bruhl T, Farhadi MR, Vajkoczy P, Hofmann WK, Peters C, Pennacchio LA, Abolmaali ND, Chavakis E, Reinheckel T, Zeiher AM, Dimmeler S.
Nature Medicine 2005 Feb; 11(2):206.
Application：WB-Ce, WB-Tr, Human, HUVEC, EPC, CD14+ monocytes, Human microvascular endothelial cells.
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Cathepsin L is required for endothelial progenitor cell-induced neovascularization.
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