BCL2 monoclonal antibody, clone Bcl-2-100
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of BCL2.
Immunogen
A synthetic peptide corresponding to human BCL2.
Host
Mouse
Theoretical MW (kDa)
26.2
Reactivity
Human
Form
Lyophilized
Purification
Affinity purification
Isotype
IgG1
Recommend Usage
Western Blot (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.4-1 ug/mL)
Immunohistochemistry (Frozen sections) (0.4-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 1.2% sodium acetate (2 mg BSA, 0.01 mg sodium azide)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 1 mL of 1.2% sodium acetate or neutral PBS and concentration will be 100 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Frozen sections)
Immunocytochemistry
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Gene Info — BCL2
Entrez GeneID
596Gene Name
BCL2
Gene Alias
Bcl-2
Gene Description
B-cell CLL/lymphoma 2
Omim ID
151430Gene Ontology
HyperlinkGene Summary
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq
Other Designations
B-cell lymphoma protein 2|OTTHUMP00000163680
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Interactome
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Pathway
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Disease
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Publication Reference
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Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death.
Hockenbery D, Nunez G, Milliman C, Schreiber RD, Korsmeyer SJ.
Nature 1990 Nov; 348(6299):334.
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Expression in non-Hodgkin's lymphoma of the bcl-2 protein associated with the t(14;18) chromosomal translocation.
Ngan BY, Chen-Levy Z, Weiss LM, Warnke RA, Cleary ML.
The New England Journal of Medicine 1988 Jun; 318(25):1638.
Application:IHC-Fr, WB-Ce, WB-Re, Human, Human follicular lymphoma, Human hematolymphoid neoplasma, Recombinant proteins, SU-DHL-4, SU-DUL-5 cells.
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Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death.
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