MMP2 monoclonal antibody, clone, 4D3
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More Files
- More Functions
Western Blot (Recombinant protein)
Western blot using MMP2 monoclonal antibody, clone, 4D3 (Cat # MAB11117) on recombinant MMP2 proenzyme (400 ng/lane).
Immunohistochemistry
Immunohistochemical staining of human oesophageal adenocarcinoma tissue using MMP2 monoclonal antibody, clone, 4D3 (Cat # MAB11117).
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant protein of human MMP2.
Immunogen
A synthetic peptide corresponding to C-terminus of human MMP2.
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1
Recommend Usage
ELISA
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-5 ug/mL)
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.08% sodium azide).
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Recombinant protein)
Western blot using MMP2 monoclonal antibody, clone, 4D3 (Cat # MAB11117) on recombinant MMP2 proenzyme (400 ng/lane).Immunohistochemistry
Immunohistochemical staining of human oesophageal adenocarcinoma tissue using MMP2 monoclonal antibody, clone, 4D3 (Cat # MAB11117).Enzyme-linked Immunoabsorbent Assay
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Gene Info — MMP2
Entrez GeneID
4313Protein Accession#
P08253Gene Name
MMP2
Gene Alias
CLG4, CLG4A, MMP-II, MONA, TBE-1
Gene Description
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
Gene Ontology
HyperlinkGene Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
collagenase type IV-A|matrix metalloproteinase 2|matrix metalloproteinase-II|neutrophil gelatinase
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Interactome
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Pathway
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Disease
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