HTRA2 monoclonal antibody, clone 1B3
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of mouse brain lysate.
Western Blot
Western blot analysis of Lane 1: 293T cell lysate; Lane 2: MCF7 cell lysate; Lane 3: HT-29 cell lysate; Lane 4: HL-60 cell lysate; Lae 5: HeLa cell lysate.
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant HTRA2.
Immunogen
Recombinant protein corresponding to amino acids 134-458 of human HTRA2.
Host
Mouse
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Isotype
IgG1, kappa
Recommend Usage
ELISA
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (10% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of mouse brain lysate.Western Blot
Western blot analysis of Lane 1: 293T cell lysate; Lane 2: MCF7 cell lysate; Lane 3: HT-29 cell lysate; Lane 4: HL-60 cell lysate; Lae 5: HeLa cell lysate.Enzyme-linked Immunoabsorbent Assay
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Gene Info — HTRA2
Entrez GeneID
27429GeneBank Accession#
NM_013247Protein Accession#
NP_037379Gene Name
HTRA2
Gene Alias
OMI, PARK13, PRSS25
Gene Description
HtrA serine peptidase 2
Gene Ontology
HyperlinkGene Summary
This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined. [provided by RefSeq
Other Designations
HtrA-like serine protease|Omi stress-regulated endoprotease|high temperature requirement protein A2|protease, serine, 25
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Interactome
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Disease
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Publication Reference
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Identification and cloning of two isoforms of human high-temperature requirement factor A3 (HtrA3), characterization of its genomic structure and comparison of its tissue distribution with HtrA1 and HtrA2.
Nie GY, Hampton A, Li Y, Findlay JK, Salamonsen LA.
The Biochemical Journal 2003 Apr; 371(Pt 1):39.
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An exegesis of IAPs: salvation and surprises from BIR motifs.
Miller LK.
Trends in Cell Biology 1999 Aug; 9(8):323.
Application：WB-Ce, WB-Tr, Human, Mammalian cells.
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Primary structure of a putative serine protease specific for IGF-binding proteins.
Zumbrunn J, Trueb B.
FEBS Letters 1996 Dec; 398(2-3):187.
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Identification and cloning of two isoforms of human high-temperature requirement factor A3 (HtrA3), characterization of its genomic structure and comparison of its tissue distribution with HtrA1 and HtrA2.
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