IKBKB monoclonal antibody, clone 10A2C5B3
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More Files
- More Functions
Western Blot (Recombinant protein)
Western blot analysis using IKBKB monoclonal antibody, clone 10A2C5B3 (Cat # MAB10696) against truncated IKBKB recombinant protein.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human colon carcinoma (A) , breast carcinoma (B) , kidney cell carcinoma (C) , bladder carcinoma tumor (D) , showing membrane and cytoplasmic localization using IKBKB monoclonal antibody, clone 10A2C5B3 (Cat # MAB10696) with DAB staining.
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant IKBKB.
Immunogen
Recombinant protein corresponding to human IKBKB.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
Western Blot (1:500-1:2000)
Immunohistochemistry (1:200-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In ascites (0.03% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Recombinant protein)
Western blot analysis using IKBKB monoclonal antibody, clone 10A2C5B3 (Cat # MAB10696) against truncated IKBKB recombinant protein.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human colon carcinoma (A) , breast carcinoma (B) , kidney cell carcinoma (C) , bladder carcinoma tumor (D) , showing membrane and cytoplasmic localization using IKBKB monoclonal antibody, clone 10A2C5B3 (Cat # MAB10696) with DAB staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — IKBKB
Entrez GeneID
3551Gene Name
IKBKB
Gene Alias
FLJ40509, IKK-beta, IKK2, IKKB, MGC131801, NFKBIKB
Gene Description
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Omim ID
603258Gene Ontology
HyperlinkGene Summary
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM
Other Designations
inhibitor of nuclear factor kappa B kinase beta subunit|nuclear factor NF-kappa-B inhibitor kinase beta
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Interactome
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Pathway
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Disease
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