Immunohistochemical analysis of paraffin-embedded human colon cancer tissues (A) and human brain tissues (B) using BCL2 monoclonal antibody, clone 8E12 (Cat # MAB10499) with DAB staining.
Immunofluorescence analysis of NIH/3T3 cells using BCL2 monoclonal antibody, clone 8E12 (Cat # MAB10499) (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
Flow cytometric analysis of 3T3-L1 cells using BCL2 monoclonal antibody, clone 8E12 (Cat # MAB10499) (green) and negative control (purple).
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq