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Last updated: 2014/11/23
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ABCG2 monoclonal antibody, clone 3G8

  • Catalog # : MAB10478
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against partial recombinant ABCG2.
  • Immunogen:
  • Recombinant protein corresponding to human ABCG2.
  • Host:
  • Mouse
  • Theoretical MW (kDa):
  • 72
  • Reactivity:
  • Human, Monkey, Mouse
  • Form:
  • Liquid
  • Isotype:
  • IgG1
  • Recommend Usage:
  • ELISA (1:10000)
    Western Blot (1:500-1:2000)
    Immunohistochemistry (1:200-1:1000)
    Immunofluorescence (1:200-1:1000)
    Flow cytometry (1:200-1:400)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In ascites (0.03% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis using ABCG2 monoclonal antibody, clone 3G8 (Cat # MAB10478) against NIH/3T3 (1) and COS-7 (2) cell lysate.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues (A) and skeletal muscle tissues (B) using ABCG2 monoclonal antibody, clone 3G8 (Cat # MAB10478) with DAB staining.
  • Immunofluorescence
  • Immunofluorescence
  • Immunofluorescence analysis of HeLa cells using ABCG2 monoclonal antibody, clone 3G8 (Cat # MAB10478) (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
  • ELISA
  • ELISA
  • ELISA detection with ABCG2 monoclonal antibody, clone 3G8 (Cat # MAB10478).
  • Flow Cytometry
  • Flow Cytometry
  • Flow cytometric analysis of HepG2 cells using ABCG2 monoclonal antibody, clone 3G8 (Cat # MAB10478) (green) and negative control (purple).
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 9429
  • Gene Name:
  • ABCG2
  • Gene Alias:
  • ABC15,ABCP,BCRP,BCRP1,BMDP,CD338,CDw338,EST157481,MGC102821,MRX,MXR,MXR1
  • Gene Description:
  • ATP-binding cassette, sub-family G (WHITE), member 2
  • Gene Summary:
  • The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. [provided by RefSeq
  • Other Designations:
  • ABC transporter,ATP-binding cassette transporter G2,ATP-binding cassette, sub-family G, member 2,breast cancer resistance protein,mitoxantrone resistance protein,placenta specific MDR protein
  • Gene Pathway
  • Related Disease
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