Immunohistochemical analysis of paraffin-embedded human lymph-node tissue (A) and human lymph follicle tissue (B), showing cytoplasmic and membrane localization using BTK monoclonal antibody, clone 7F12H4 (Cat # MAB10456) with DAB staining.
Immunofluorescence analysis of Jurkat cells using BTK monoclonal antibody, clone 7F12H4 (Cat # MAB10456).
The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. [provided by RefSeq