EIF4EBP1 monoclonal antibody, clone 11G12C11
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More Files
- More Functions
Western Blot (Recombinant protein)
Western blot analysis using EIF4EBP1 monoclonal antibody, clone 11G12C11 (Cat # MAB10437) against truncated EIF4EBP1 recombinant protein (1).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human pancreas carcinoma (A), esophagus carcinoma tissue (B) and ovary tumor tissue, showing cytoplasmic and membrane localization using EIF4EBP1 monoclonal antibody, clone 11G12C11 (Cat # MAB10437) with DAB staining.
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant EIF4EBP1.
Immunogen
Recombinant protein corresponding to human EIF4EBP1.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
Immunohistochemistry (1:200-1:1000)
Immunofluorescence (1:200-1:1000)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.03% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Recombinant protein)
Western blot analysis using EIF4EBP1 monoclonal antibody, clone 11G12C11 (Cat # MAB10437) against truncated EIF4EBP1 recombinant protein (1).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human pancreas carcinoma (A), esophagus carcinoma tissue (B) and ovary tumor tissue, showing cytoplasmic and membrane localization using EIF4EBP1 monoclonal antibody, clone 11G12C11 (Cat # MAB10437) with DAB staining.Immunofluorescence
Enzyme-linked Immunoabsorbent Assay
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Gene Info — EIF4EBP1
Entrez GeneID
1978Gene Name
EIF4EBP1
Gene Alias
4E-BP1, 4EBP1, BP-1, MGC4316, PHAS-I
Gene Description
eukaryotic translation initiation factor 4E binding protein 1
Omim ID
602223Gene Ontology
HyperlinkGene Summary
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq
Other Designations
eIF4E-binding protein 1|phosphorylated heat- and acid-stable protein regulated by insulin 1
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Interactome
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Pathway
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Disease
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