HLA-G monoclonal antibody, clone MEM-G/2
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry staining of kidney allograft biopsy (paraffin - embedded sections) with human HLA - G monoclonal antibody, clone MEM - G/2 (Cat # MAB0968) .
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant HLA-G.
Immunogen
Recombinant protein corresponding to heavy chain region (denaturated) of human HLA-G.
Host
Mouse
Reactivity
Human
Specificity
This antibody recognizes the free heavy chain of all the HLA-G isoforms.
Form
Liquid
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS, pH 7.4 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry staining of kidney allograft biopsy (paraffin - embedded sections) with human HLA - G monoclonal antibody, clone MEM - G/2 (Cat # MAB0968) . -
Gene Info — HLA-G
Entrez GeneID
3135Gene Name
HLA-G
Gene Alias
MHC-G
Gene Description
major histocompatibility complex, class I, G
Gene Ontology
HyperlinkGene Summary
HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq
Other Designations
HLA class I molecule|HLA-G histocompatibility antigen, class I, G|MHC class I antigen|OTTHUMP00000039485|b2 microglobulin
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Interactome
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Pathway
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Disease
- Abortion
- Anemia
- Arthritis
- Asthma
- Autoimmune Diseases
- Behcet Syndrome
- Birth Weight
- Bronchial Hyperreactivity
- Carcinoma
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Publication Reference
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In focus in HCB.
Douglas J Taatjes, Jürgen Roth.
Histochemistry and Cell Biology 2022 Dec; 158(6):513.
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HLA-G as a prognostic marker in stage II/III colorectal cancer: not quite there yet.
Alessandro Gambella, Stefano Scabini, Gabriele Zoppoli, Annalisa De Silvestri, Simona Pigozzi, Michele Paudice, Michela Campora, Roberto Fiocca, Federica Grillo, Luca Mastracci.
Histochemistry and Cell Biology 2022 Dec; 158(6):535.
Application：IHC, Human, Colorectal cancer tissues.
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Predictive value of HLA-G and HLA-E in the prognosis of colorectal cancer patients.
Guo ZY, Lv YG, Wang L, Shi SJ, Yang F, Zheng GX, Wen WH, Yang AG.
Cellular Immunology 2015 Jan; 293(1):10.
Application：IHC, Human, Colorectal cancer tissues.
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In focus in HCB.
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