PTPRC monoclonal antibody, clone MEM-28

Catalog # MAB0886

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Size:100 ug
Price: USD $ 329.00
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Contact Info
  • +1-909-264-1399
    +1-909-992-0619
    Toll Free : +1-877-853-6098
  • +1-909-992-3401
Images
Flow Cytometry
Application

Flow Cytometry

Surface staining of human peripheral blood cells with PTPRC monoclonal antibody, clone MEM - 28 (Cat # MAB0886) APC.

Immunofluorescence (Circulating Tumor Cell)
Application

Immunofluorescence (Circulating Tumor Cell)

PBMCs were stained with CD45-R-PE labeled monoclonal antibody (Red). The cell nucleus were counterstained with DAPI (Blue).

Immunofluorescence
Application

Immunofluorescence

Immunofluorescence of monoclonal antibody to CD45 on PBMCs cell . [antibody concentration 10 ug/ml]

  • Specifications

    Product Description

    Mouse monoclonal antibody raised against native PTPRC.

    Immunogen

    Native purified PTPRC from human thymocytes and T lymphocytes.

    Host

    Mouse

    Theoretical MW (kDa)

    180-220

    Reactivity

    Human

    Specificity

    This antibody reacts with all alternative forms of human CD45 antigen (Leukocyte Common Antigen), a 180-220 KDa single chain type I transmembrane protein expressed at high level on all cells of hematopoietic origin, except erythrocytes and platelets.

    Form

    Liquid

    Concentration

    1 mg/mL

    Isotype

    IgG1

    Recommend Usage

    The optimal working dilution should be determined by the end user.

    Storage Buffer

    In PBS, pH 7.4 (0.09% sodium azide)

    Storage Instruction

    Store at 4°C. Do not freeze.

    Note

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

  • Applications

    Western Blot

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

    Immunoprecipitation

    Flow Cytometry

    Surface staining of human peripheral blood cells with PTPRC monoclonal antibody, clone MEM - 28 (Cat # MAB0886) APC.

    Immunofluorescence (Circulating Tumor Cell)

    PBMCs were stained with CD45-R-PE labeled monoclonal antibody (Red). The cell nucleus were counterstained with DAPI (Blue).

    Immunofluorescence

    Immunofluorescence of monoclonal antibody to CD45 on PBMCs cell . [antibody concentration 10 ug/ml]
  • Gene Info — PTPRC

    Entrez GeneID

    5788

    Gene Name

    PTPRC

    Gene Alias

    B220, CD45, CD45R, GP180, LCA, LY5, T200

    Gene Description

    protein tyrosine phosphatase, receptor type, C

    Omim ID

    126200 151460 609532

    Gene Ontology

    Hyperlink

    Gene Summary

    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq

    Other Designations

    CD45 antigen|T200 glycoprotein|T200 leukocyte common antigen|glycoprotein|leukocyte-common antigen|protein tyrosine phosphatase, receptor type, c polypeptide

  • Interactomes
  • Pathways
  • Diseases
Contact Info
  • +1-909-264-1399
    +1-909-992-0619
    Toll Free : +1-877-853-6098
  • +1-909-992-3401
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