ITGB2 monoclonal antibody, clone MEM-48
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Specification
Product Description
Mouse monoclonal antibody raised against native ITGB2.
Immunogen
Native purified ITGB2 from leukocytes of a patient suffering from a LGL-type leukemia.
Host
Mouse
Theoretical MW (kDa)
90-95
Reactivity
Human
Specificity
This antibody recognizes an epitope involving residues 534-546 in cysteine-rich repeat 3 of the CD18 antigen (integrin beta 2 subunit; beta 2 integrin).
Form
Liquid
Purification
Differential precipitation and solid-phase chromatography methods
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS, pH 7.4 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blotting analysis (non - reducing conditions) of whole cell lysate using ITGB2 monoclonal antibody, clone MEM - 48 (Cat # MAB0880) . Lane 1 : KG - 1a human acute myeloid leukemia cell line. Lane 2 : HPB - ALL human peripheral blood T cell leukemia cell line.Immunohistochemistry (Frozen sections)
Immunoprecipitation
Flow Cytometry
Surface staining of human peripheral blood cells with ITGB2 monoclonal antibody, clone MEM - 48 (Cat # MAB0880) PE. Cells in the granulocyte gate were used for analysis. -
Gene Info — ITGB2
Entrez GeneID
3689Gene Name
ITGB2
Gene Alias
CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7
Gene Description
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Gene Ontology
HyperlinkGene Summary
The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq
Other Designations
CD18 subunit|OTTHUMP00000115278|OTTHUMP00000115279|OTTHUMP00000115281|OTTHUMP00000115282|beta 2 integrin subunit|cell surface adhesion glycoprotein LFA-1/CR3/P150,959 beta subunit precursor)|complement receptor C3 beta-subunit|integrin beta 2|integrin bet
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